Regulator of G Protein Signaling 6 (RGS6) Protein Ensures Coordination of Motor Movement by Modulating GABAB Receptor Signaling
نویسندگان
چکیده
منابع مشابه
Regulator of G protein signaling 6 (RGS6), a multifarious and pleiotropic modulator of G protein coupled receptor signaling in brain
γ-Aminobutyric acid (GABA) release from Golgi cells, inhibitory interneurons located within the cerebellar cortex, limits the extent of granule cell excitation in part through activation of metabatropic GABAB receptors (GABABRs). Stimulation of these receptors triggers a number of downstream signaling events including activation of G protein-activated inwardly rectifying potassium (GIRK) channe...
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Regulator of G protein signaling (RGS) proteins act to temporally modulate the activity of G protein subunits after G proteincoupled receptor activation. RGS proteins exert their effect by directly binding to the activated G subunit of the G protein, catalyzing the accelerated hydrolysis of GTP and returning the G protein to its inactive, heterotrimeric form. In previous studies, we have sought...
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Conserved structural motifs on pathogens trigger pattern recognition receptors present on APCs such as dendritic cells (DCs). An important class of such receptors is the Toll-like receptors (TLRs). TLR signaling triggers a cascade of events in DCs that includes modified chemokine and cytokine production, altered chemokine receptor expression, and changes in signaling through G protein-coupled r...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.297218